Ethanol → (Hexahydro-1H-furo[3,4-c]pyrrol-3a-yl)methanamine

HRID 53881Notes

Reaction equation

HRID 53881 reaction equation
[NH2:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[CH2:6]C[CH2:4]2.C([OH:13])C>[Pd]>[NH2:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[CH2:6][O:13][CH2:4]2

Participants

4

Reactant 2

HCID 702EthanolHCID 22924372HCID 22924372, compound

Product 1

HCID 19960957(Hexahydro-1H-furo[3,4-c]pyrrol-3a-yl)methanamine

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

2.8 g (12.1 mmol) of 1-aminomethyl-7-azabicyclo[3.3.0]octane are dissolved in 50 ml of ethanol and hydrogenated on 0.3 g of palladium-active charcoal at 100° C. and 100 bar. The catalyst is filtered off with suction and the filtrate is concentrated and distilled. Yield: 1.5 g (87% of theory) Boiling point: 70°-72° C./0.03 mbar.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationdistilled

Sources & evidence

ORD record
ord-b30132afecb2478d999c28d547f5e513
Source dataset
uspto-grants-1997_04
Patent number
US05621105

Reaction notes

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