Gamma-Aminobutyric Acid → HCID 86691668, compound

Participants

Reaction Steps

γ-Aminobutyric acid (25.8 g, 250 mmol), allyl alcohol (100 mL, 1.50 mol) and p-toluenesulfonic acid (48.5 g, 255 mmol) were suspended in 100 mL of toluene and the suspension was refluxed for 16 h under a water separator. Subsequently, the orange solution was concentrated under reduced pressure. Following complete crystallization of the residue, it was thoroughly washed with diethyl ether (4×300 ml). The product was obtained as a colorless solid (77.8 g, 99%).

Provenance & Evidence