HCID 86694360, compound → HCID 86694359, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl (1R*,2S*,5S*)-6-oxabicyclo[3.1.0]hexan-2-yl((2-nitrophenyl)sulfonyl)-carbamate (2.0 g, 5.10 mmol) in MeOH (40 mL) was added Amberlyst 15 (4.0 g) and the resulting suspension was stirred for 1.5 h at 25° C. The reaction mixture was filtered and concentrated. The title compound was obtained after purification by flash chromatography (heptane-EtOAc 90:10→EtOAc) as a beige solid (1.24 g, 73%): TLC (heptane/EtOAc 1:2) Rf=0.36; tR=0.80 min (UPLC 1), tR, 0.77 min (LC-MS 3); ESI-MS: 346 [M+NH4]+ (LC-MS 3).

Provenance & Evidence