Tetrabutylammonium Fluoride → HCID 71715824, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (4S,5R)-3-(2′-amino-2-morpholino-4′-(trifluoromethyl)-[4,5′-bipyrimidin]-6-yl)-5-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-4-methyloxazolidin-2-one (2.1 g, 3 mmol) in THF (20 mL), was added dropwise 1M TBAF in THF (3 mL, 3 mmol) at 0° C. The reaction mixture was stirred for 1 h at 0° C. before evaporation. The residue was purified by flash chromatography (hexane/EtOAc/MeOH 90:10:1→0:100:10). The purified product was re-crystallized from MeOH to afford the title compound as a white solid (1.17 g, 83%): tR=0.80 min (UPLC 1), tR=0.82 min (LC-MS 3); ESI-MS: 470 [M+H]+ (LC-MS 3).

Provenance & Evidence