(4S)-4-(propan-2-yl)-1,3-oxazolidin-2-one → HCID 67034436, compound

HRID 538985Notes

Reaction equation

HRID 538985 reaction equation
[CH:1]([C@H:4]1[CH2:8][O:7][C:6](=[O:9])[NH:5]1)([CH3:3])[CH3:2].Cl[C:11]1[CH:16]=[CH:15][N:14]2[N:17]=[CH:18][CH:19]=[C:13]2[N:12]=1.Br[C:21]1[CH:22]=NN2C=CC(Cl)=N[C:25]=12>>[C:1]1([C@H:4]2[CH2:8][O:7][C:6](=[O:9])[N:5]2[C:11]2[CH:16]=[CH:15][N:14]3[N:17]=[CH:18][CH:19]=[C:13]3[N:12]=2)[CH:3]=[CH:22][CH:21]=[CH:25][CH:2]=1

Participants

4

Reactant 3

HCID 7157133(4S)-4-(propan-2-yl)-1,3-oxazolidin-2-oneHCID 210717595-Chloropyrazolo(1,5-a)pyrimidineHCID 454805073-Bromo-5-chloropyrazolo(1,5-a)pyrimidine

Product 1

HCID 67034436HCID 67034436, compoundYield 77%

Procedure

(S)-4-Phenyl-3-(pyrazolo[1,5-a]pyrimidin-5-yl)oxazolidin-2-one (0.423 g, 77%) was prepared by the procedure described in Example 1, Step 4, substituting (S)-4-phenyloxazolidin-2-one (0.638 g, 3.91 mmol) for (S)-4-isopropyloxazolidin-2-one and 5-chloropyrazolo[1,5-a]pyrimidine (0.300 g, 1.95 mmol) for 3-bromo-5-chloropyrazolo[1,5-a]pyrimidine.

Sources & evidence

ORD record
ord-77419b9f844943bc8a43410e65dc4479
Source dataset
uspto-grants-2014_10
Patent number
US08865726B2

Reaction notes

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