5-Chloropyrazolo(1,5-a)pyrimidine → HCID 67034661, compound

HRID 539010Notes

Reaction equation

HRID 539010 reaction equation
[CH:1]([C@H:4]1[CH2:8][N:7]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)[C:6](=[O:18])[NH:5]1)([CH3:3])[CH3:2].Cl[C:20]1[CH:25]=[CH:24][N:23]2[N:26]=[CH:27][CH:28]=[C:22]2[N:21]=1>>[CH:1]([C@H:4]1[CH2:8][N:7]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)[C:6](=[O:18])[N:5]1[C:20]1[CH:25]=[CH:24][N:23]2[N:26]=[CH:27][CH:28]=[C:22]2[N:21]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 210717595-Chloropyrazolo(1,5-a)pyrimidineHCID 68089262HCID 68089262, compound

Product 1

HCID 67034661HCID 67034661, compoundYield 54.2%

Procedure

(S)-4-Isopropyl-1-(4-methoxybenzyl)-3-(pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one (0.386 g, 52%) was prepared by the procedure described in Example 1, Step 4, from (S)-4-isopropyl-1-(4-methoxybenzyl)imidazolidin-2-one (0.500 g, 2.01 mmol) and 5-chloropyrazolo[1,5-a]pyrimidine (0.300 g, 1.95 mmol). LCMS (APCI+) m/z 366 [M+H]+.

Sources & evidence

ORD record
ord-5dbfc91fb9d948719e8287551a2c8fc9
Source dataset
uspto-grants-2014_10
Patent number
US08865726B2

Reaction notes

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