HCID 67034111, compound → HCID 178423425, compound

Participants

Reaction Steps

(4S)-4-isopropyl-3-(3-(2-methyl-4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)oxazolidin-2-one (0.250 g, 80%) was prepared by the procedure described in Example 1, Step 9, using a mixture of (4S)-4-isopropyl-3-(3-(2-methyl-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)oxazolidin-2-one and (4S)-4-isopropyl-3-(3-(2-methyl-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-5-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)oxazolidin-2-one (0.414 g, 0.776 mmol), to produce a yellow solid. LCMS (APCI+) m/z 404.6 [M+H]+; 1H-NMR (400 MHz, CDCl3) δ 11.07 (broad s, 1H), 8.61 (d, J=7.8 Hz, 1H), 8.22 (m, 2H), 8.03 (d, J=7.8 Hz, 1H), 7.99 (s, 1H), 7.88 (d, J=7.7 Hz, 1H), 7.72 (d, J=8.1 Hz, 1H), 4.84-4.80 (m, 1H), 4.38-4.30 (m, 2H), 2.72-2.64 (m, 1H), 2.51 (s, 3H), 0.94 (d, J=7.0 Hz, 3H), 0.88 (d, J=6.8 Hz, 3H).

Provenance & Evidence