HCID 67033328, compound → HCID 178448162, compound

Participants

Reaction Steps

(S)-3-(3-(3-Chloro-4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-isopropyloxazolidin-2-one (0.051 g, 25%) was prepared by the procedure described in Example 1, Step 9, using a mixture of (S)-3-(3-(3-chloro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-isopropyloxazolidin-2-one and (S)-3-(3-(3-chloro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-5-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-isopropyloxazolidin-2-one (0.270 g, 0.487 mmol), to produce a yellow solid. LCMS (APCI+) m/z 424.6 [M+H]+; 1H-NMR (400 MHz, DMSO-d6) δ 14.21 (broad s, 1H), 9.13 (d, J=7.8 Hz, 1H), 8.83 (s, 1H), 8.67 (s, 1H), 8.39 (m, 1H), 8.09 (m, 1H), 7.95-7.82 (m, 2H), 4.96-4.92 (m, 1H), 4.56-4.50 (m, 2H), 2.80-2.76 (m, 1H), 1.07 (d, J=7.1 Hz, 3H), 0.86 (d, J=6.8 Hz, 3H).

Provenance & Evidence