Sodium hydride → HCID 67033996, compound

Participants

Reaction Steps

To a stirred solution of (S)-benzyl 1-cyclopropyl-3-hydroxypropan-2-ylcarbamate (0.734 g, 2.94 mmol) in DMF (15 mL) was added sodium hydride (0.177 g, 4.42 mmol) at 0° C. The mixture was then stirred at ambient temperature for 30 minutes. The solvent was concentrated and the residue distributed between water and EtOAc. The combined organic extracts were dried (phase separator silicone treated filter paper), concentrated to provide (S)-4-(cyclopropylmethyl)oxazolidin-2-one (0.318 g, 76% yield) as a clear oil.

Provenance & Evidence