Hydrochloric Acid → (R)-2-amino-2-(2,4-difluorophenyl)ethanol hydrochloride

Participants

Reaction Conditions

Reaction Steps

To a mixture of (S)—N—((R)-2-(tert-butyldimethylsilyloxy)-1-(2,4-difluorophenyl)ethyl)-2-methylpropane-2-sulfinamide (1.08 g, 2.76 mmol) in MeOH (8 mL) was added 4N HCl in dioxane (6.9 mL, 28 mmol) at 0° C. under N2. The reaction mixture was stirred at 0° C. for 4 hours. The solvents were evaporated in vacuo to give (R)-2-amino-2-(2,4-difluorophenyl)ethanol hydrochloride (0.58 g, 100%) as a white solid, which was used in the next step without further purification.

Provenance & Evidence