4-Bromo-1,2-difluorobenzene → HCID 67033201, compound

HRID 539091Notes

Reaction equation

HRID 539091 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([F:9])[CH:3]=1.[Si:10]([O:17][CH2:18]/[CH:19]=[N:20]/[S@@:21]([C:23]([CH3:26])([CH3:25])[CH3:24])=[O:22])([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:12])[CH3:11]>>[Si:10]([O:17][CH2:18][C@@H:19]([NH:20][S@@:21]([C:23]([CH3:26])([CH3:25])[CH3:24])=[O:22])[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([F:9])[CH:3]=1)([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:12])[CH3:11]

Participants

3

Reactant 2

HCID 676754-Bromo-1,2-difluorobenzeneHCID 12060937HCID 12060937, compound

Product 1

HCID 67033201HCID 67033201, compoundYield 65%

Procedure

(R)—N—((S)-2-(tert-butyldimethylsilyloxy)-1-(3,4-difluorophenyl)ethyl)-2-methylpropane-2-sulfinamide (4.12 g, 65%) was prepared by the procedure described in Example 99, Step 1, using 4-bromo-1,2-difluorobenzene and (R,E)-N-(2-(tert-butyldimethylsilyloxy)ethylidene)-2-methylpropane-2-sulfinamide.

Sources & evidence

ORD record
ord-8b73b1b382804d56ab6ac1fb9de384cc
Source dataset
uspto-grants-2014_10
Patent number
US08865726B2

Reaction notes

Loading…