Pyrrole-2-Carboxylic Acid → HCID 67033510, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(2-bromophenyl)oxazolidin-2-one (497 mg, 2.05 mmol), 1H-pyrrole-2-carboxylic acid (137 mg, 1.23 mmol), tert-butyl piperazine-1-carboxylate (765 mg, 4.11 mmol), copper(I) iodide (117 mg, 0.616 mmol) and K3PO4 (1.74 g, 8.21 mmol) in DMSO (15 mL) was heated at 90° C. for 8 hours. After cooling, the reaction mixture was partitioned between EtOAc and water. The aqueous layer was extracted with EtOAc. The combined organic layers were washed with brine, dried and concentrated. The residue was purified by column chromatography (hexane/EtOAc, 1:1) to give tert-butyl 4-(2-(2-oxooxazolidin-4-yl)phenyl)piperazine-1-carboxylate (462 mg, 65%).

Provenance & Evidence