反应详情

A mixture of (S)-3-(3-(3-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-methoxyphenyl) oxazolidin-2-one (0.0424 g, 0.071 mmol) in DCM (1 mL) was treated with trifluoroacetic acid (0.5 mL) at ambient temperature. The mixture was stirred for 18 hours. The solvent was concentrated and the residue was partitioned between EtOAc and saturated aqueous NaHCO3. The aqueous layer was further extracted with EtOAc and DCM. The combined organic extracts were washed with brine, dried, and concentrated, and the crude material was purified by column chromatography (silica, 10% MeOH/dichloromethane) to afford the title compound (0.011 g, 33%) as a yellow solid. MS (APCI+) m/z 472 [M+H]+.

1. concentrationThe solvent was concentrated
2. customthe residue was partitioned between EtOAc and saturated aqueous NaHCO3
3. extractionThe aqueous layer was further extracted with EtOAc and DCM
4. washThe combined organic extracts were washed with brine
5. customdried
6. concentrationconcentrated
7. customthe crude material was purified by column chromatography (silica, 10% MeOH/dichloromethane)