Hydrochloric Acid → HCID 67033321, compound

Participants

Reaction Steps

(S)—N—((S)-2-(tert-butyldimethylsilyloxy)-1-(4-methylpyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide (1.10 g, 2.97 mmol) was dissolved in MeOH (15 ml), and treated with 3.7 ml of a 4.0 M hydrogen chloride solution in dioxane. The reaction was stirred at ambient temperature for 2 hours, concentrated to dryness, and stored under high vacuum overnight to provide 0.71 g (106%) of crude (S)-2-amino-2-(4-methylpyridin-2-yl)ethanol dihydrochloride which was used directly in the next step.

Provenance & Evidence