Hydrochloric Acid → HCID 68490959, compound

Participants

Reaction Steps

To a solution of 13 (190 mg, 0.236 mmol) in THF (4 mL) was added a solution of LiOH (8.48 mg, 0.354 mmol) in H2O (1 mL) at 0° C. After stirring for 1 h CHCl3 (60 mL) was added to the solution followed by 1M HCl (10 mL). The layers were separated and the aqueous phase washed with CHCl3 (2×10 mL). The organic layers were combined, washed with brine, dried with MgSO4 and concentrated in vacuo. The crude material was then purified by flash column chromatography on silica gel (eluent 2% MeOH/CH2Cl2) to give 14 (80 mg, 0.1 mmol, 43%) as a pale yellow solid: Rf 0.21 AcOH/MeOH/CH2Cl2/(1:4:95).

Provenance & Evidence