反应详情

温度

120 °C

A stirred suspension of 2,6-dinitroaniline (5 g, 27.3 mmol) in glacial acetic acid (50 mL) was added bromine (1.5 mL, 30 mmol) dropwise and heated at 120° C. for 2 h. After cooling to ambient temperature, the resultant mixture was poured into water (50 mL). The precipitate solid was collected by filtration and washed with water then dried in-vacuo. The solid was re-dissolved in EtOAC, washed with water and saturated brine. The organic layer was collected and concentrated in-vacuo to give the desired product (6.88 g, 95%). 1H NMR (300 MHz, DMSO-d6) δ ppm 8.37 (br s, 2H), 8.58 (s, 2H).

1. temperatureAfter cooling to ambient temperature
2. filtrationThe precipitate solid was collected by filtration
3. washwashed with water
4. customthen dried in-vacuo
5. dissolutionThe solid was re-dissolved in EtOAC
6. washwashed with water and saturated brine
7. customThe organic layer was collected
8. concentrationconcentrated in-vacuo