Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium Hydroxide → N-((N-Methyl-N-((2-pyridinyl)methyl)amino)carbonyl)valine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | (S)-3-Methyl-2-[[methyl-(2-pyridinylmethyl)amino]carbonyl]aminobutyric acid methyl ester | HCID 10039258 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | N-((N-Methyl-N-((2-pyridinyl)methyl)amino)carbonyl)valine | HCID 10106914 | 85% |
반응 단계
A solution of 4.47 g (16 mmol) of N-((N-methyl-N-((2-pyridinyl)methyl)amino)carbonyl)valine methyl ester in 65 ml of dioxane was treated with 65 ml of 0.5M aqueous lithium hydroxide. After being stirred at ambient temperature for 1 h, the resulting solution was concentrated in vacuo to a small volume (ca. 5 ml), neutralized to pH 5 with 1M aqueous HCl, and extracted with three 100 ml portions of ethyl acetate. The combined organic layers were dried over Na2SO4 and concentrated in vacuo to provide 3.61 g (85%) of the desired compound as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05621109 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-7c8d0ff29ca94e1f87524cff123dacd9 |
| 출처 메모 | uspto-grants-1997_04 |