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6'-Bromo-5''-methyl-3'H-dispiro[cyclobutane-1,2'-indene-1',2''-imidazol]-4''-amine → US8865911, 57 Isomer 1
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6'-Bromo-5''-methyl-3'H-dispiro[cyclobutane-1,2'-indene-1',2''-imidazol]-4''-amine | HCID 57386666 | — |
| 反応物 | 5-(1-Propynyl)pyridine-3-boronic Acid (contains varying amounts of Anhydride) | HCID 57416482 | — |
| 生成物 | US8865911, 57 Isomer 1 | HCID 57386668 | 68% |
反応手順
The title compound (60 mg, 68% yield) was prepared by the method described in Example 55, starting from 6′-bromo-5″-methyl-3′H-dispiro[cyclobutane-1,2′-indene-1′,2″-imidazol]-4″-amine (Example 54) (80 mg, 0.25 mmol) and 5-(prop-1-ynyl)pyridin-3-ylboronic acid (Intermediate 15, 53 mg, 0.33 mmol). 1H NMR (500 MHz, DMSO-d6) δ ppm 1.59 (m, 4 H) 1.83 (d, 1 H) 2.09 (s, 3 H) 2.16 (d, 1 H) 2.21 (s, 3 H) 3.23 (m, 2 H) 6.60 (s, 2 H) 6.89 (d, 1 H) 7.41 (d, 1 H) 7.54 (dd, 1 H) 7.91 (t, 1 H) 8.52 (d, 1 H) 8.67 (d, 1 H). MS (ES+) m/z 355 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08865911B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-b0e0fb189d294568bbb4ae9fe8f16798 |
| 出典メモ | uspto-grants-2014_10 |