HRID539397

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68959007

未命名化合物

结构：O=Cc1ccc(C(=O)C(Cc2ncc[nH]2)Cc2ncc[nH]2)cc1

HCID86630101

未命名化合物

PRODUCTS

生成物

结构：Cc1ccsc1CN1CCC2(CC1)CCN(Cc1ccc(C(=O)C(Cc3ncc[nH]3)Cc3ncc[nH]3)cc1)C2

HCID57685529

未命名化合物

收率 14.7%

PROCEDURE

实验过程

Using the compound (64 mg) produced in Example 13 and the compound (54 mg) produced in Example 11, the same operation as in Example 12 was performed. The resulting residue was purified by silica gel chromatography (ethyl acetate:methanol:28% aqueous ammonia=100:10:2) to obtain the title compound (14 mg) having the following physical properties.

WORKUP

后处理

customThe resulting residue was purified by silica gel chromatography (ethyl acetate:methanol:28% aqueous ammonia=100:10:2)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-95a4d0812cce43ecb644fda7af1b105c
来源数据集: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08871210B2
来源说明: uspto-grants-2014_10

反应 SMILES

[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH2:7][N:8]1[CH2:17][CH2:16][C:11]2([CH2:15][NH:14][CH2:13][CH2:12]2)[CH2:10][CH2:9]1.[NH:18]1[CH:22]=[CH:21][N:20]=[C:19]1[CH2:23][CH:24]([CH2:35][C:36]1[NH:37][CH:38]=[CH:39][N:40]=1)[C:25]([C:27]1[CH:34]=[CH:33][C:30]([CH:31]=O)=[CH:29][CH:28]=1)=[O:26]>>[NH:18]1[CH:22]=[CH:21][N:20]=[C:19]1[CH2:23][CH:24]([CH2:35][C:36]1[NH:37][CH:38]=[CH:39][N:40]=1)[C:25]([C:27]1[CH:28]=[CH:29][C:30]([CH2:31][N:14]2[CH2:13][CH2:12][C:11]3([CH2:10][CH2:9][N:8]([CH2:7][C:3]4[S:4][CH:5]=[CH:6][C:2]=4[CH3:1])[CH2:17][CH2:16]3)[CH2:15]2)=[CH:33][CH:34]=1)=[O:26]