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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 539405Generated: October 30, 2026

8-Cyclohexyl-2,8-diazaspiro[4.5]decane → 8-cyclohexyl-2-(4-{3-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-2-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]propoxy}benzoyl)-2,8-diazaspiro[4.5]decane

https://huagongshe.com/reaction/539405

Reaction equation

Participants

RoleNameHCIDCharge
Reactant8-Cyclohexyl-2,8-diazaspiro[4.5]decaneHCID 67500672—
Reactant4-{3-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-2-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]propoxy}benzoic AcidHCID 68958419—
Product8-cyclohexyl-2-(4-{3-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-2-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]propoxy}benzoyl)-2,8-diazaspiro[4.5]decaneHCID 6895284380.1%

Reaction Steps

Except for using the compound (50 mg) produced in Example 103 in place of the compound produced in Example 68 and using 8-cyclohexyl-2,8-diazaspiro[4.5]decane (38 mg) in place of the compound produced in Example 91, the same operation as in Example 92 was performed to obtain the title compound (54 mg) having the following physical properties.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08871210B2
Source datasetuspto-grants-2014_10
ORD IDord-96941bfb7f0f49e8bbe6f6867b35e3cb
Source noteuspto-grants-2014_10