HCID 86690060, compound → HCID 86690061, compound

Participants

Reaction Steps

4-((4-Phenoxyphenyl)sulfonyl)-4-(((tetrahydro-2H-pyran-2-yl)oxy)carbamoyl)piperidine was synthesized as shown in FIG. 13. A 200 ml RBF equipped with magnetic stir bar was charged with the 1.5 g of benzyl 4-((4-phenoxyphenyl)sulfonyl)-4-(((tetrahydro-2H-pyran-2-yl)oxy)carbamoyl)piperidine-1-carboxylate compound and 100 mg wet Degussa 5% Palladium on Carbon in 45 ml Methanol. The reaction mixture was purged with Argon for 5 minutes. Hydrogen was then bubbled over the solution for 1 hr. MS analysis (direct infusion) at this point indicated that the reaction was complete. The crude was filtered through Celite and the Celite was washed with 40 ml additional methanol. The methanol solution was concentrated in vacuo to 1.2 g white solid that was vacuum dried for 4 hours to yield 1.1 g product that was used in Step 5. HRMS(observed) M H=451.1737 g/mol.

Provenance & Evidence