HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenethylamine, (+)- → N-(1-Phenylethyl)amino-3-hydroxy-2,3,4,5-tetrahydrofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenethylamine, (+)- | HCID 643189 | — |
| Reactant | Trimethylaluminum | HCID 16682925 | — |
| Reactant | 3,4-Epoxy-2,5-dihydrofuran | HCID 22013150 | — |
| Product | N-(1-Phenylethyl)amino-3-hydroxy-2,3,4,5-tetrahydrofuran | HCID 86750710 | — |
Reaction Steps
According to the procedure of Overman, et al. (J. Org. Chem. 1985, 50, 4154), 3,4-epoxy-2,5-dihydrofuran was treated with (R)-1-phenylethylamine and trimethylaluminum to give a 1:1 mixture of diastereomers. The mixture was purified by silica gel chromatography to provide the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05621109 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-9af0bce2d775476eaf671bad4fa92694 |
| Source note | uspto-grants-1997_04 |