反应详情

Reaction of 3-benzyloxypyridine-2-one (0.50 g, 2.49 mmol) and 156d (0.62 g, 2.98 mmol) within 16 h as described for synthesis of 157a gave compound 157d (0.49 g, 63%) as a colorless oil. 1H NMR (400 MHz, CDCl3) δ 7.35 (d, J=8.0 Hz, 2H), 7.23 (m, 3H), 6.81 (m, 1H), 6.56 (m, 1H), 5.94 (m, 1H), 5.01 (s, 2H), 3.85 (m, 2H), 3.18 (m, 2H), 1.71 (m, 2H), 1.54 (m, 2H), 1.32 (m, 2H). 13C NMR (100 MHz, CDCl3) δ 157.68, 148.47, 135.98, 128.60, 128.12, 127.53, 126.93, 115.09, 104.32, 70.27, 50.77, 49.21, 28.19, 28.06, 23.37. HRMS (EI) calcd for C17H20N4O2 [M]+ 312.1586. found 312.1589.