反应详情

Reaction of phenylacetylene (0.124 g, 1.21 mmol) and 157c (0.30 g, 1.01 mmol) within 4 h as described for synthesis of 158a gave compound 158c (0.31 g, 77%) as a white solid. 1H NMR (400 MHz, CDCl3) δ 7.83 (s, 1H), 7.76 (m, 2H), 7.26 (m, 8H), 6.76 (dd, J=6.9, 1.5 Hz, 1H), 6.56 (dd, J=7.4, 1.5 Hz, 1H), 5.91 (t, J=7.1 Hz, 1H), 4.99 (s, 2H), 4.31 (m, 2H), 3.89 (t, J=7.1 Hz, 2H), 1.85 (m, 2H), 1.67 (m, 2H). 13C NMR (100 MHz, CDCl3) δ 157.71, 148.38, 147.20, 135.83, 130.29, 128.45, 128.41, 128.16, 127.68, 127.63, 126.96, 125.25, 119.87, 114.99, 104.60, 70.26, 49.11, 48.02, 26.78, 25.65. HRMS (EI) calcd for C24H24N4O2 [M]+ 400.1899. found 400.1888.