反应详情

Reaction of phenylacetylene (0.80 g, 0.78 mmol) and 157e (0.21 g, 0.65 mmol) within 4 h as described for synthesis of 158a gave compound 158e (0.16 g, 56%) as a white solid. NMR (400 MHz, CDCl3) δ 7.66 (m, 3H), 7.20 (m, 8H), 6.68 (dd, J=6.9, 1.5 Hz, 1H), 6.46 (dd, J=7.4, 1.5 Hz, 1H), 5.82 (t, J=7.1 Hz, 1H), 4.92 (s, 2H), 4.18 (t, J=6.8 Hz, 2H), 3.75 (t, J=6.8 Hz, 2H), 1.76 (m, 2H), 1.56 (m, 2H), 1.19 (m, 4H). 13C NMR (100 MHz, CDCl3) δ 157.64, 148.46, 147.27, 135.95, 130.36, 128.57, 128.48, 128.19, 127.72, 127.60, 126.96, 125.32, 119.37, 115.02, 104.37 70.45, 50.03, 49.35, 29.90, 28.66, 25.87, 25.78. HRMS (FAB) calcd for C26H29N4O2 [M+H]+ 429.2290. found 429.2291.