HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → HCID 57788120, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 6-Aminoisoquinoline | HCID 588991 | — |
| Reactant | 2-Amino-3,4-dimethylpyridine | HCID 11007884 | — |
| Reactant | HCID 68602053 | HCID 68602053 | — |
| Product | HCID 57788120 | HCID 57788120 | — |
Reaction Steps
To (R)-2-Boc-2-phenylacetic acid in DMF was added EDC, dimethyl aminopyridine (“DMAP”) and 6-aminoisoquinoline. This mixture was stirred for 4 hours and the reaction was washed with NaHCO3 (sat), extracted with EtOAc, dried (Na2SO4), filtered and evaporated. Column chromatography (SiO2, Hexanes/EtOAc) gave pure (R)-tert-butyl-2-(isoquinolin-6-ylamino)-2-oxo-1 phenyl-ethylcarbamate (E1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871757B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-062df20f6b474463b96d20231fc8b89f |
| Source note | uspto-grants-2014_10 |