HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 44198503, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 66906141 | HCID 66906141 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 44198503 | HCID 44198503 | — |
Reaction Steps
To (R)-2-amino-N-(isoquinolin-6-yl)-2-phenylacetamide dihydrochloride (E2) in MeOH was added CH2O (37%), AcOH and NaCNBH3. After stirring for 1.5 hours the solution was poured into NaHCO3(sat) and extracted with EtOAc, dried (Na2SO4), filtered and concentrated. Column chromatography Hexanes/EtOAc gave pure (R)-2-(dimethylamino)-N-(isoquinolin-6-yl)-2-phenylacetamide. To (R)-2-(dimethylamino)-N-(isoquinolin-6-yl)-2-phenylacetamide was added CH2Cl2 and HCl (4N in dioxane) and the solvents were evaporated to give pure (R)-2-(dimethylamino)-N-(isoquinolin-6-yl)-2-phenylacetamide dihydrochloride (E3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871757B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-1ebe883917934c34a19fceebbd821af7 |
| Source note | uspto-grants-2014_10 |