HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 539569Generated: October 31, 2026
Pyridine → (R)-tert-butyl 2-fluoro-2 oxo-1-(thiophen-3-yl)ethylcarbamate
https://huagongshe.com/reaction/539569
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Cyanuric fluoride | HCID 12664 | — |
| Reactant | (R)-2-((tert-Butoxycarbonyl)amino)-2-(thiophen-3-yl)acetic acid | HCID 7023006 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (R)-tert-butyl 2-fluoro-2 oxo-1-(thiophen-3-yl)ethylcarbamate | HCID 57788121 | — |
Reaction Steps
To (R)-2-(tert-butoxycarbonylamino)-2-(thiophen-3-yl)acetic acid in CH2Cl2 cooled to −10° C. was added pyridine and cyanuric fluoride. The solution was stirred for 1 hour at −10° C., quenched with ice and extracted with CH2Cl2 and ice cold water, dried (Na2SO4), filtered and evaporated to give (R)-tert-butyl 2-fluoro-2 oxo-1-(thiophen-3-yl)ethylcarbamate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08871757B2 |
|---|
| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-3012d4375c3c421ba803fd302eede819 |
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| Source note | uspto-grants-2014_10 |
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