HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(tert-butoxycarbonyl)glycine → HCID 76281969, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 76281968 | HCID 76281968 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 76281969 | HCID 76281969 | — |
Reaction Steps
A solution of Example 42 (1.0 equiv.) in CH2Cl2 (˜0.1 M) was treated with 2-((tert-butoxycarbonyl)amino)acetic acid (1.2 equiv.), followed by HATU (1.1 equiv(2.5 equiv.). The resulting mixture was allowed to stir at rt for two hours, and then was filtered and treated with one volume of TFA. The resulting solution was allowed to stir at rt for 30 minutes, and the solvents were removed under reduced pressure. The residue was purified by mass-triggered HPLC to provide the desired product. ESI-MS (m/z): [M+H]+ 425.1, RT 1.1033 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871754B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-87024e59382b4c5d8dc453f85ca10b68 |
| Source note | uspto-grants-2014_10 |