Hydrazine → HCID 178514313, compound

HRID 539629Notes

Reaction equation

HRID 539629 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[N:3]=1.[NH2:15][NH2:16]>O1CCOCC1.O>[F:14][C:11]1[CH:12]=[CH:13][C:8]([C:4]2[NH:3]/[C:2](=[N:15]\[NH2:16])/[CH:7]=[N:6][CH:5]=2)=[CH:9][CH:10]=1

Participants

5

Reactant 2

HCID 9321HydrazineHCID 545956102-Chloro-6-(4-fluorophenyl)pyrazine(WXFC0484)

Product 1

HCID 178514313HCID 178514313, compoundYield 88.6%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

A mixture of 2-chloro-6-(4-fluoro-phenyl)-pyrazine (1.0 g, 4.7 mmol) and anhydrous hydrazine (1.5 mL, 47 mmol) in dioxane (20 mL) was heated to reflux for two hours, then cooled and diluted with cold water. The resulting precipitate was collected by filtration, washed with cold water, and dried to give 0.85 g of [6-(4-fluoro-phenyl)-1H-pyrazin-(2Z)-ylidene]-hydrazine.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for two hours
  3. temperaturecooled
  4. filtrationThe resulting precipitate was collected by filtration
  5. washwashed with cold water
  6. customdried

Sources & evidence

ORD record
ord-3b0c630d70ee45a486a85b0ebabb3a5e
Source dataset
uspto-grants-2014_10
Patent number
US08871760B2

Reaction notes

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