Water → Ethyl 4-acetoxybenzoylformate

HRID 53963Notes

Reaction equation

HRID 53963 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1.[C:15](OC(=O)C)(=[O:17])[CH3:16].O>N1C=CC=CC=1>[C:15]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:6][CH:7]=1)(=[O:17])[CH3:16]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 11715332Ethyl 2-(4-hydroxyphenyl)-2-oxoacetate

Product 1

HCID 10977426Ethyl 4-acetoxybenzoylformate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

7.25 g of ethyl 2-(4-hydroxyphenyl)-2-oxoacetate was dissolved in 15 ml of pyridine, followed by adding 4 ml of acetic anhydride and then stirring at room temperature for 1 hour. The resulting reaction solution was poured into water, and extracted with diethyl ether. The resulting organic layer was washed with water, and then concentrated to dryness. Thereafter, the residue was dissolved in benzene, and then concentrated to obtain 8.3 g of the title compound in an oily form.

Workup

  1. customThe resulting reaction solution
  2. extractionextracted with diethyl ether
  3. washThe resulting organic layer was washed with water
  4. concentrationconcentrated to dryness
  5. dissolutionThereafter, the residue was dissolved in benzene
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-02e77db4390d4786a4126f8714e8aa93
Source dataset
uspto-grants-1997_04
Patent number
US05620991

Reaction notes

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