Semicarbazide → 5-{1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-1H-pyrazol-3-yl}-2-methyl-phenylamine Semicarbazide

HRID 539642Notes

Reaction equation

HRID 539642 reaction equation
[C:1]([Si:5]([CH3:24])([CH3:23])[O:6][CH2:7][CH2:8][N:9]1[C:13]([CH3:14])=[CH:12][C:11]([C:15]2[CH:16]=[CH:17][C:18]([CH3:22])=[C:19]([NH2:21])[CH:20]=2)=[N:10]1)([CH3:4])([CH3:3])[CH3:2].[NH2:25][NH:26][C:27]([NH2:29])=[O:28].C(Cl)(Cl)=O.NN>>[NH2:25][NH:26][C:27]([NH2:29])=[O:28].[C:1]([Si:5]([CH3:24])([CH3:23])[O:6][CH2:7][CH2:8][N:9]1[C:13]([CH3:14])=[CH:12][C:11]([C:15]2[CH:16]=[CH:17][C:18]([CH3:22])=[C:19]([NH2:21])[CH:20]=2)=[N:10]1)([CH3:3])([CH3:2])[CH3:4]

Participants

5

Reactant 4

HCID 5196SemicarbazideHCID 6371PhosgeneHCID 9321HydrazineHCID 66955104HCID 66955104, compound

Product 1

HCID 670436225-{1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-1H-pyrazol-3-yl}-2-methyl-phenylamine Semicarbazide

Procedure

5-{1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-1H-pyrazol-3-yl}-2-methyl-phenylamine was converted to the corresponding semicarbazide by treatment with phosgene followed by hydrazine, as described above in step 4 of preparation 7.

Workup

  1. customas described above in step 4 of preparation 7

Sources & evidence

ORD record
ord-a0eef354119748a3b4927fe6397d47c3
Source dataset
uspto-grants-2014_10
Patent number
US08871760B2

Reaction notes

Loading…