Hydrochloric Acid → HCID 58200262, compound

Participants

Reaction Steps

To a stirring room temperature solution of {1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-1H-indazol-6-yl}-[(R)-5-(4-fluoro-phenyl)-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-yl]-amine (110 mg, 0.21 mmol) in MeOH (5 mL) was added 6N aqueous HCl (0.5 mL). The mixture was stirred at room temperature for 15 minutes and then concentrated under reduced pressure. The residue was recrystallized from MeOH/EtOAc/diethyl ether to give 70 mg of 2-{6-[(R)-5-(4-fluoro-phenyl)-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-ylamino]-5-methyl-indazol-1-yl}-ethanol, MP=215-217° C., MS (M+H)=409.

Provenance & Evidence