HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 539654Generated: October 31, 2026
Chlorotrimethylsilane → Methyl 2-(pyridin-2-yl)thiazole-4-carboxylate
https://huagongshe.com/reaction/539654
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-(Pyridin-2-yl)-1,3-thiazole-4-carboxylic acid | HCID 15623090 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-(pyridin-2-yl)thiazole-4-carboxylate | HCID 57688390 | — |
Reaction Steps
To a solution of 2-(pyridin-2-yl)thiazole-4-carboxylic acid 7.4 (500 mg, 2.425 mmol) in commercial anhydrous methanol (10 mL) was added TMS-Cl (0.77 mL, 6.06 mmol) at once. The RM was heated to 50° C. overnight. The RM. was concentrated under reduced pressure and the residue was used crude in next step. Yield: 649 mg (quantitative). LCMS: P=94%, rt=4.07 nm, m/z=221.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08871761B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-f6020b528dc1424eaa9182b681f7e14c |
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| Source note | uspto-grants-2014_10 |
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