HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(Pyrimidin-4-yl)benzoic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 2-(pyrimidin-4-yl)benzoate | HCID 86680852 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-(Pyrimidin-4-yl)benzoic acid hydrochloride | HCID 86680853 | — |
Reaction Steps
A mixture of methyl 2-(pyrimidin-4-yl)benzoate (0.49 g), acetic acid (2.0 mL) and 6 N hydrochloric acid (10 mL) was heated under reflux for 5 hr. The solvent was evaporated under reduced pressure, and the obtained residue was washed with ethyl acetate to give the title compound (0.45 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871766B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-cc4be7e183604fe9ba2a4ce2aab13dc7 |
| Source note | uspto-grants-2014_10 |