反应详情

温度

80 °C

To a mixture of ethyl 2-chloronicotinate (23 g), tributyl(1-ethoxyvinyl)tin (64 mL) and toluene (400 mL) was added tetrakis(triphenylphosphine)palladium(0) (7.3 g), and the mixture was stirred overnight at 80° C. under an argon atmosphere. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane), and then purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (27 g).

1. customThe solvent was evaporated under reduced pressure
2. customthe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)
3. custompurified by silica gel column chromatography (ethyl acetate/hexane)