反应详情

To a stirred solution of 5-(6-methoxyimidazo[1,2-b]pyridazin-2-yl)-2-methylaniline (0.050 g, 0.206 mmol) in acetonitrile (5 mL) containing pyridine (0.618 mmol) is added trimethylacetylchloride (0.206 mmol). The mixture is stirred at room temperature for 4 hours, concentrated to dryness, then purified via chromatography (hexanes to EtOAc) to afford the title compound (0.060 g, 86%) as a white solid: Rf 0.57 (EtOAc); LCMS (m/z)=339.4 [M+H]+, tR=6.37 min. (10 min run)

1. concentrationconcentrated to dryness
2. custompurified via chromatography (hexanes to EtOAc)