2-Amino-5-chloropyridine → 6-Chloro-2-[3-nitro-4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyridine

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Reaction Steps

A solution of 2-amino-5-chloropyridine (0.064 g, 0.5 mmol) and 2-bromo-1-[3-nitro-4-(trifluoromethyl)phenyl]ethanone (0.156 g, 0.5 mmol) in acetonitrile (3 ml) is stirred at 100° C. for 18 hr. The mixture is concentrated and purified on silica (0 to 100% EtOAc in hexanes) to give the title compound (165 mg, 97% yield). LCMS m/z=342.3 [M+H]+, tR=2.86 min.

Provenance & Evidence