Cyclopropylamine → HCID 57516203, compound

Participants

Reaction Conditions

Reaction Steps

A solution of cyclopropanamine (0.025 mL, 0.369 mmol) in acetonitrile (1 mL) is added 5-(6-ethoxyimidazo[1,2-b]pyridazin-2-yl)-2-(trifluoromethyl)benzene-1-sulfonyl chloride (0.123 mmol). The mixture is stirred at 60° C. for 12 hours. The mixture is concentrated to dryness and then purified via chromatography using a gradient of hexanes to EtOAc to afford 0.035 g (67%) of the title compound as a white solid: LCMS (m/z)=427.4 [M+H]+, tR=2.76 min. (compound same as Example 212)

Provenance & Evidence