Acetic Acid → HCID 57516208, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(4-ethynyl-3-nitrophenyl)-6-(2-fluorophenyl)imidazo[1,2-b]pyridazine (0.050 g, 0.139 mmol) in ethanol (3 mL) and water (1 mL) containing AcOH (0.834 mmol) is added iron (0.038 g, 0.695 mmol). The mixture is stirred and heated at 80° C. for 2 hours, then concentrated under reduced pressure and sat. aqueous NaHCO3 (20 mL) is added. The mixture is extracted with EtOAc (3×20 mL). Organic layer is collected, dried over Na2SO4, filtered and concentrated to dryness. The crude product is purified via chromatography using a gradient of hexanes to EtOAc to afford the title compound (0.033 g, 73%) as a yellow solid: Rf 0.30 (1:1 EtOAc:hexanes); LCMS (m/z)=329.4 [M+H]+, tR=2.65 min. (compound same as Example 320)

Provenance & Evidence