HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Amino-3-chloropyridazine → 6-Chloro-2-(4-ethyl-3-nitrophenyl)imidazo[1,2-b]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Amino-3-chloropyridazine | HCID 21643 | — |
| Reactant | 2-Bromo-1-(4-ethyl-3-nitrophenyl)ethanone | HCID 57516280 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 6-Chloro-2-(4-ethyl-3-nitrophenyl)imidazo[1,2-b]pyridazine | HCID 57516228 | 62% |
Reaction Steps
A solution of 6-chloropyridazin-3-amine (4.76 g, 0.037 mol) and 2-bromo-1-(4-ethyl-3-nitrophenyl)ethanone (10.0 g, 0.037 mol) in acetonitrile (100 mL) is heated at reflux for 18 hr. The reaction mixture is diluted with water (500 mL), stirred at room temperature for 1 hour and solids are collected by filtration to give the title compound (6.9 g, 62% yield). LCMS m/z=303.3, 305.4 [M+H]+, tR=2.90 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871767B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-c41cc3cb6f3a45d498ce7fc8d3cc4d61 |
| Source note | uspto-grants-2014_10 |