反应详情

3.42 g of 3,4-diaminobenzonitrile and 4.06 g of ethyl chloroacetoimidate hydrochloride were dissolved in 100 ml of ethanol, and the solution was refluxed under heating for 3 hours. After cooling and distilling off the solvent, the resulting residue was dissolved in ethyl acetate, washed with water, and then dried. After distilling off the solvent, the crystals thus precipitated were collected by filtration to obtain 2.7 g of 2-chloromethyl-5-benzimidazolecarbonitrile.

1. temperaturethe solution was refluxed
2. temperatureunder heating for 3 hours
3. temperatureAfter cooling
4. distillationdistilling off the solvent
5. dissolutionthe resulting residue was dissolved in ethyl acetate
6. washwashed with water
7. customdried
8. distillationAfter distilling off the solvent
9. customthe crystals thus precipitated
10. filtrationwere collected by filtration