Methyl iodide → HCID 136197397, compound

Participants

Reaction Steps

The compound (2.7 g, 6 mmol) of example 35 was suspended in methanol (20 ml), and added with iodomethane (1.0 g, 7 mmol). After refluxed for 3 h, the reaction mixture was concentrated to dryness. The resultant solid was recrystallized from ethylether to obtain the title compound (2.4 g, yield: 85%). 1H NMR (DMSO-d6) δ: 7.16 (1H, d), 6.99 (1H, dd), 6.87 (1H, d), 4.00 (2H, t), 3.37 (1H, m), 2.94 (2H, q), 2.56 (3H, s), 1.74 (2H, m), 1.18 (6H, d), 1.11 (3H, t), 0.98 (3H, t).

Provenance & Evidence