Ethyl isocyanate → HCID 136330921, compound

HRID 539871Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:19][CH2:20][CH2:21][CH3:22])=[C:6]([C:8]2[NH:13][C:12](=[O:14])[C:11]([CH2:15][CH3:16])=[C:10]([CH2:17][CH3:18])[N:9]=2)[CH:7]=1.[CH2:23]([N:25]=[C:26]=[O:27])[CH3:24]>>[CH2:17]([C:10]1[N:9]=[C:8]([C:6]2[CH:7]=[C:2]([NH:1][C:26]([NH:25][CH2:23][CH3:24])=[O:27])[CH:3]=[CH:4][C:5]=2[O:19][CH2:20][CH2:21][CH3:22])[NH:13][C:12](=[O:14])[C:11]=1[CH2:15][CH3:16])[CH3:18]

Participants

Reactant 2

HCID 8022Ethyl isocyanate

HCID 136197415HCID 136197415, compound

Product 1

HCID 136330921HCID 136330921, compoundYield 90%

Procedure

The title compound was prepared by reacting the compound of example 42 with ethyl isocyanate in the same manner as that of example 35. Yield: 90%. 1H NMR (DMSO-d6) δ: 11.76 (1H, br), 8.46 (1H, br), 7.77 (1H, d), 7.57 (1H, dd), 7.06 (1H, d), 6.01 (1H, t), 4.00 (2H, t), 3.09 (2H, m), 2.56 (2H, q), 2.45 (2H, q), 1.73 (2H, m), 1.19 (3H, t), 1.03 (6H, t), 0.97 (3H, t).

Sources & evidence

ORD record: ord-90f4e5c03e354b6ab72fe11240a21e1b
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08871777B2

Reaction notes

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