Methanesulfonyl chloride → HCID 135890156, compound

HRID 539878Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[CH:4][C:5]([O:19][CH2:20][CH2:21][CH3:22])=[C:6]([C:8]2[NH:13][C:12](=[O:14])[C:11]([CH2:15][CH3:16])=[C:10]([CH2:17][CH3:18])[N:9]=2)[CH:7]=1.[S:23](Cl)([CH3:26])(=[O:25])=[O:24]>>[S:23]([O:1][C:2]1[CH:3]=[CH:4][C:5]([O:19][CH2:20][CH2:21][CH3:22])=[C:6]([C:8]2[NH:13][C:12](=[O:14])[C:11]([CH2:15][CH3:16])=[C:10]([CH2:17][CH3:18])[N:9]=2)[CH:7]=1)(=[O:25])(=[O:24])[CH3:26]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 136197392HCID 136197392, compound

Product 1

HCID 135890156HCID 135890156, compound

Procedure

The title compound was prepared by reacting the compound of example 81 with mesyl chloride in the same manner as that of example 50. 1H NMR (CDCl3) δ: 8.39 (1H, d), 7.43 (1H, dd), 7.06 (1H, d), 4.18 (2H, t), 3.20 (3H, s), 2.68 (2H, q), 2.58 (2H, q), 2.00 (2H, m), 1.28 (3H, t), 1.14 (6H, t).

Sources & evidence

ORD record: ord-44cfd4f44a3f48ffb301b3bb8b891aa5
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08871777B2

Reaction notes

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