1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 135890168, compound

Participants

Reaction Steps

N-Boc-4-aminobutyric acid (203 mg, 1 mmol) was dissolved in dichloromethane (50 ml), and added with EDCI (180 mg, 1 mmol) and HOBT (135 mg, 1 mmol), followed by stirring at room temperature for 12 h. The compound of example 42 (300 mg, 1 mmol) was added thereinto and the stirring continued at room temperature for 6 h. The reaction mixture was washed with water (50 ml) and saturated saline (50 ml) respectively. The organic layer was dried with anhydrous sodium sulfate, and concentrated, and the residue was passed through a silica gel column to give the white title compound (200 mg, yield: 41%). 1H NMR (CDCl3) δ: 9.00 (1H, br), 8.39 (1H, d), 8.09 (1H, dd), 6.99 (1H, d), 4.83 (1H, t), 4.14 (2H, t), 3.27 (2H, m), 2.65 (2H, q), 2.59 (2H, q), 2.41 (2H, t), 1.97 (2H, m), 1.89 (2H, m), 1.48 (9H, s), 1.29 (3H, t), 1.14 (3H, t), 1.13 (3H, t).

Provenance & Evidence