1-methyl-1H-pyrrole-2-ethylamine → HCID 136330833, compound

HRID 539884Notes

Reaction equation

HRID 539884 reaction equation
[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=O)=[CH:7][C:6]=1[C:14]1[NH:15][C:16](=[O:24])[C:17]([CH2:22][CH3:23])=[C:18]([CH2:20][CH3:21])[N:19]=1)[CH2:2][CH3:3].[CH3:25][N:26]1[CH:30]=[CH:29][CH:28]=[C:27]1[CH2:31][CH2:32][NH2:33]>>[CH2:20]([C:18]1[N:19]=[C:14]([C:6]2[CH:7]=[C:8]([CH:12]=[CH:13][C:5]=2[O:4][CH2:1][CH2:2][CH3:3])[C:9]([NH:33][CH2:32][CH2:31][C:27]2[N:26]([CH3:25])[CH:30]=[CH:29][CH:28]=2)=[O:11])[NH:15][C:16](=[O:24])[C:17]=1[CH2:22][CH3:23])[CH3:21]

Participants

3

Reactant 2

HCID 5650581-methyl-1H-pyrrole-2-ethylamineHCID 136197410HCID 136197410, compound

Product 1

HCID 136330833HCID 136330833, compound

Procedure

According to the same manner as that of example 89, the compound of example 58 was reacted with 2-(1-methylpyrrol-2-yl)ethylamine to give the compound of example 117. 1H NMR (DMSO-d6) δ: 12.01 (1H, br), 8.50 (1H, t), 8.12 (1H, d), 7.96 (1H, dd), 7.22 (1H, d), 4.08 (2H, t), 3.28 (2H, m), 2.98 (1H, m), 2.58 (2H, q), 2.47 (2H, q), 2.25 (3H, s), 2.13 (2H, m), 1.90 (2H, m), 1.75 (2H, m), 1.64 (2H, m), 1.45 (2H, m), 1.19 (3H, t), 1.04 (3H, t), 0.96 (3H, t).

Sources & evidence

ORD record
ord-e293d92f8e1d4ed394e96b3647f22f31
Source dataset
uspto-grants-2014_10
Patent number
US08871777B2

Reaction notes

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