Ethyl isocyanate → HCID 135890115, compound

Participants

Reaction Steps

The compound (0.33 g, 1 mmol) of example 195 was dissolved in ethanol (10 ml), and added with ethyl isocyanate (0.8 g, 1.1 mmol). After refluxed for 1 h, the reaction mixture was concentrated to dryness. The resultant solid was recrystallized from ethyl acetate-petroleum ether to obtain the title compound (0.32 g, yield: 80%). 1H NMR (DMSO-d6) δ: 11.81 (1H, br), 7.58 (1H, d), 7.30 (1H, dd), 7.19 (1H, d), 5.65 (1H, t), 4.07 (2H, t), 3.55 (2H, q), 3.00 (2H, m), 2.56 (2H, q), 2.46 (2H, q), 1.77 (2H, m), 1.18 (3H, t), 1.04 (3H, t), 0.99 (3H, t), 0.98 (3H, t), 0.95 (3H, t).

Provenance & Evidence