Chlorine → HCID 135890118, compound

HRID 539888Notes

Reaction equation

[CH:1]([C:4]1[N:9]=[C:8]([C:10]2[CH:15]=[C:14]([S:16]([N:19]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]3)(=[O:18])=[O:17])[CH:13]=[CH:12][C:11]=2[O:26][CH2:27][CH2:28][CH3:29])[NH:7][C:6](=[O:30])[CH:5]=1)([CH3:3])[CH3:2].[Cl:31]Cl>>[Cl:31][C:5]1[C:6](=[O:30])[NH:7][C:8]([C:10]2[CH:15]=[C:14]([S:16]([N:19]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]3)(=[O:18])=[O:17])[CH:13]=[CH:12][C:11]=2[O:26][CH2:27][CH2:28][CH3:29])=[N:9][C:4]=1[CH:1]([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 24526Chlorine

HCID 136236333HCID 136236333, compound

Product 1

HCID 135890118HCID 135890118, compound

Procedure

The compound of example 221 was prepared by reacting the compound of example 1 with chlorine gas in the same manner as that of example 207. 1H NMR (CDCl3) 8.86 (1H, d), 7.88 (1H, dd), 7.16 (1H, d), 4.27 (2H, t), 3.49 (1H, m), 3.09 (4H, t), 2.50 (4H, t), 2.27 (3H, s), 2.03 (2H, m), 1.26 (6H, d), 1.16 (3H, t).

Sources & evidence

ORD record: ord-ba371d09eb3a46a09a7da15c6b5a4496
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08871777B2

Reaction notes

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