Dimethylformamide → HCID 86698982, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-cyclopropyl-1H-pyrazole-4-carbaldehyde (5.4 g, 30.0 mmol) in 100 mL of anhydrous N,N-dimethylformamide were added potassium carbonate (10.4 g, 75 mmol) and 2,4-dichloropyrimidine (7.1 g, 30.0 mmol) at room temperature. The resulting suspension was stirred for 6 hours at 60° C. with monitoring a reaction with LC-MS or thin layer chromatography (TLC). Volatiles were removed and the residue was extracted with dichloromethane. The collected organic layer was washed with brine, dried over anhydrous sodium sulfate and then concentrated in vacuo. The resulting solid was recrystallized in acetonitrile to afford the desired intermediate 4 as a pale yellow solid (6.0 g, 68%); MS (ESI) m/z 293 [M+H]+.

Provenance & Evidence